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In vitro glycosylation assays. (A) YM155 structure. (B) SDS-PAGE analysis of recombinant proteins. (C) Western blot results for YM155 inhibition of NleB1, NleB, and SseK1 glycosylation of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and SseK2 glycosylation of Fas-associated protein with death domain (FADD). (D) Quantification of western blot signal intensities, n = 3. (E) UDP Glo Assay. O-linked N-acetylglucosaminyltransferase (OGT) activity as a function of [YM155], n = 3.
