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. 2021 Feb 22;13(4):914. doi: 10.3390/cancers13040914

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Epigenetic changes involved in tumour–stroma crosstalk in ovarian cancer (OC) cells. Fibroblasts and MSC (mesenchymal stem cells) can both influence and be influenced by OC cells. In both represented mechanisms, epigenetic modifications play a pivotal role. Fibroblasts in OC TME are involved in a TNFα/TGF-α/EGFR (epidermal growth factor receptor) loop activated by DNA hypomethylation, which sustains cancer cells invasion and metastasis. OC cells mediate mesenchymal to epithelial transition (MET) in MSC by the activation of the epigenetic regulator EZH2 (enhancer of zeste homolog 2).