Figure 7.

Disorder propensities of individual proteins generated by the cleavage of ORF1ab protein from MERS-CoV. Plots show the positions of cleavage sites within disorder profiles at the junctions between the cleaved products. (A) Cleavage site between host translation inhibitors nsp1 and nsp2. (B) Cleavage site between nsp2 and papain-like proteinase. (C) Cleavage site between papain-like proteinase and nsp4. (D) Cleavage site between nsp4 and 3C-like proteinase. (E) Cleavage site between 3C-like proteinase and nsp6. (F) Cleavage site between nsp6 and nsp7. (G) Cleavage site between nsp7 and nsp8. (H) Cleavage site between nsp8 and nsp9. (I) Cleavage site between nsp9 and nsp10. (J) Cleavage site between non-structural protein 11 and RNA-directed RNA polymerase. (K) Cleavage site between RNA-directed RNA polymerase and helicase. (L) Cleavage site between helicase and guanine-N7 methyltransferase. (M) Cleavage site between guanine-N7 methyltransferase and uridylate-specific endoribonuclease. (N) Cleavage site between uridylate-specific endoribonuclease and 2’-O-methyltransferase.