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. 2021 Feb 23;13(2):171. doi: 10.3390/toxins13020171

Table 3.

Effects of mycotoxin-detoxifying agents on the growth performance of pigs challenged with deoxynivalenol, alone or in combination with other mycotoxins.

Mycotoxin, Concentration (mg/kg) n BW Range (kg) Duration (days) Mycotoxin-Detoxifying Agent Change in Growth Performance (%) Reference
Inorganic Yeast Other ADG ADFI G:F
DON, 1 120 10 to 20 23 Acid-activated bentonite and clinoptilolite Yeast cell wall Organic acids +5.0 +4.7 0.0 [60]
DON, 2.3 36 7.5 to 16.5 21 - Hydrolyzed yeast cell wall Organic acids, vitamins, and essential oils +5.4 +5.6 +9.0 [57]
DON, 2.6 120 7 to 10 14 Acid-activated bentonite and clinoptilolite Yeast cell wall Organic acids +28.9 +19.8 +7.5 [60]
DON, 3.2 36 8.19 to 20.73 34 Bentonite Yeast culture Diatomaceous earth and kelp +11.8 +4.7 +6.0 [13]
DON, 3.2 36 8.19 to 20.55 34 Organo-aluminosilicate clays Yeast cell walls Plant extracts, triglycerides, calcium propionate, and antioxidants +7.4 +3.1 +4.5 [13]
DON, 3.2 36 8.21 to 20.44 34 Sepiolite and bentonite Inactivated yeast and fermentation extracts Propyl gallate, calcium propionate, milk thistle seed, rosemary, licorice root, and boldo +4.1 −0.8 +3.0 [13]
DON, 3.82 30 6.9 to 11.2 14 - - Sodium metabisulfite, organic acids, vitamins, and amino acids +60.0 +13.8 +36.2 [64]
DON, 4.2 126 13.4 to 22.4 21 Adsorbent clays - Preservatives −10.1 −9.0 −1.6 [63]
DON, 4.41 30 7.0 to 10.9 14 - Yeast extract Live bacteria, enzymes, and plant extracts +19.5 +12.8 +5.2 [64]
DON, 4.66 30 6.9 to 10.6 14 - Yeast glucomannan - +1.8 +6.9 −8.6 [64]
DON, 4.65 30 6.9 to 10.7 14 Aluminosilicate - - +7.3 0.0 +6.9 [64]
DON, 4.45; FB1, 0.76; ZEA, 0.44 780 22.9 to 104.6 115 - - Sodium metabisulfite, organic acids, vitamins, and amino acids +9.1 +5.6 +3.0 [40]
DON, 4.45; FB1, 0.76; ZEA, 0.44 780 22.8 to 103.3 115 Hydrated sodium calcium aluminosilicate and silicon dioxide Hydrolyzed yeast - +4.5 +3.4 +0.8 [40]
AFL, 0.18; FUM, 9; DON, 1 48 6 to 29 36 Hydrated sodium calcium aluminosilicate Yeast cell wall Algae 0.0 −3.9 +4.3 [65]

BW, body weight; ADG, average daily gain; ADFI, average daily feed intake; G:F, gain-to-feed ratio; AFL, aflatoxins; DON, deoxynivalenol; FUM, fumonisins; ZEA, zearalenone; FB1, fumonisin B1.