Table 2.
The top 5 pathways of KEGG enrichment analysis results.
| Toxin | Top 5 Pathways | Downregulated Genes | Upregulated Genes | p-Value | Count |
|---|---|---|---|---|---|
| 3-ADON | DNA replication | PCNA, MCM4, MCM3, MCM5, MCM6, MCM7, MCM2, POLD1, RFC3, FEN1, POLE2, RFC4, RPA3, RNASEH2A, POLE3, LIG1, POLD3, PRIM1, POLA2, POLD2, RPA1, RFC5, POLE, RNASEH1, RFC2, POLA1, RNASEH2C | − | 1.06 × 10−16 | 27 |
| Cell cycle | PCNA, MCM4, E2F1, MCM3, MCM5, CDC6, MCM6, MAD2L1, MCM7, MCM2, CDK1, CCNB1, PTTG1, E2F2, ORC6, CHEK2, CCNA2, CCND1, YWHAB, CDC45, PKMYT1, E2F3, ORC1, CDC25A, CCNE1, CDK2, CDKN2C, ESPL1, TFDP1, CHEK1, BUB1, DBF4, PLK1, RBX1, BUB1B, CDKN2A, CDC25C, MAD2L2, CDC7, CCNE2, SMC1B, CCND3, CDKN2D, CCND2 | WEE2, STAG1, STAG2, ATM | 2.74 × 10−12 | 48 | |
| Base excision repair | PCNA, PARP1, POLD1, FEN1, POLE2, POLE3, UNG, LIG1, POLD3, NEIL3, NTHL1, POLE, PARP2, NEIL2, HMGB1, POLD2 | NEIL1, PARP4 | 3.53 × 10−8 | 18 | |
| Fanconi anemia pathway | RMI2, UBE2T, RAD51, CENPX, RPA3, EME1, RPA1, TELO2, FANCI, FANCA, FANCG, FANCD2, BRCA1, FANCM, BLM, FANCB, FAAP24, RAD51C, CENPS, CENPS-CORT, ATRIP | EME2, POLK, POLI | 3.58 × 10−8 | 24 | |
| Homologous recombination | POLD1, RAD51, RPA3, RAD54L, EME1, POLD3, RPA1, POLD2, XRCC2, BRCA1, RAD54B, XRCC3, RBBP8, BLM, BARD1, RAD51C | ATM, ABRAXAS1 | 2.31 × 10−6 | 18 | |
| DON | DNA replication | PCNA, MCM4, MCM3, MCM5, MCM6, MCM2, MCM7, POLD1, POLD2, RFC3, POLE2, RFC4, FEN1, RPA3, RNASEH1, POLE3, LIG1, POLD3, RNASEH2A, PRIM1, POLA2, RFC2, RNASEH2C | − | 1.17 × 10−13 | 23 |
| Base excision repair | PCNA, PARP1, POLD1, UNG, POLD2, POLE2, FEN1, POLE3, LIG1, POLD3, NEIL2, HMGB1, NTHL1 | PARP4, NEIL1 | 1.10 × 10−6 | 15 | |
| Cell cycle | PCNA, E2F1, MCM4, MCM3, MCM5, E2F2, MCM6, MCM2, MCM7, CCND1, CDK2, MAD2L1, CDC6, ORC6, CCNE1, CDKN2C, TFDP1, CHEK2, CDC45, E2F3, ESPL1, PKMYT1, CDC25A, ORC1, CCND3, CDKN2A, MAD2L2, CDKN2B, CCND2 | WEE2, STAG1, STAG2, ATM | 2.69 × 10−6 | 33 | |
| Steroid hormone biosynthesis | CYP1A1, UGT1A6, HSD17B8, HSD11B2, UGT1A4, UGT1A1 | UGT2A3, UGT2B15, UGT2B17, AKR1C2, UGT2B7, UGT2B11, STS, AKR1C1, AKR1C3, CYP17A1, CYP3A5, SULT1E1, UGT2B10, AKR1D1 | 9.00 × 10−6 | 20 | |
| Drug metabolism—other enzymes | TK1, NME1, NME4, DUT, NME2, HPRT1, IMPDH1, UCK2, UGT1A6, UPP1, TK2, MGST1, UGT1A4, CDA, UGT1A1 | UGT2A3, GSTA2, UGT2B15, UGT2B17, UGT2B7, UGT2B11, GSTA1, UGT2B10 | 1.81 × 10−5 | 23 | |
| 15-ADON | DNA replication | PCNA, MCM3, MCM4, MCM5, POLD1, MCM6, MCM2, MCM7, POLE2, POLD2, RFC4, RFC3, RPA3, LIG1, POLE3, RNASEH1, PRIM1, POLD3, POLA2, RFC2 | − | 1.54 × 10−11 | 20 |
| Cell cycle | PCNA, MCM3, E2F1, MCM4, MCM5, E2F2, CDK2, TFDP1, MCM6, CCND1, MAD2L1, MCM2, MCM7, ANAPC5, CCNE1, CDKN2C, CHEK2, E2F3, ORC6, CDC45, ORC1, PKMYT1, CDC25A, MAD2L2, CCND3, CCND2 | WEE2, STAG1, ATM, CDKN2B | 4.03 × 10−6 | 30 | |
| Base excision repair | PCNA, PARP1, UNG, POLD1, POLE2, POLD2, LIG1, POLE3, POLD3, NTHL1, NEIL2 | NEIL1, OGG1 | 8.87 × 10−6 | 13 | |
| Pyrimidine metabolism | TYMS, NME1, TK1, NME4, DUT, DTYMK, UCK2, CAD, NME2, DCK, UPP1, TK2, DCTPP1, DHODH, CDA | ENTPD8, AK9 | 2.92 × 10−5 | 17 | |
| Mismatch repair | PCNA, POLD1, POLD2, RFC4, RFC3, EXO1, RPA3, LIG1, POLD3, RFC2 | − | 3.57 × 10−5 | 10 |
“−” indicates no upregulated genes were found in corresponding pathways.