Table 1.

Diagnostic criteria for drug-induced hypersensitivity syndrome (DIHS) established by a Japanese consensus group [1].

1	Maculopapular rash developing > 3 weeks after starting with a limited number of drugs
2	Prolonged clinical symptoms 2 weeks after discontinuation of the causative drug
3	Fever (>38 °C)
4	Liver abnormalities (alanine aminotransferase > 100 U·L−1) a
5	Leukocyte abnormalities (at least one present)
a	Leukocytosis (>11 × 109 L−1)
b	Atypical lymphocytosis (>5%)
c	Eosinophilia (>1.5 × 109 L−1)
6	Lymphadenopathy
7	Human herpesvirus 6 reactivation

The diagnosis is confirmed by the presence of the seven criteria above (typical DIHS) or of the five (1~5) (atypical DIHS). ^a This can be replaced by other organ involvement, such as renal involvement.