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. 2021 Feb 23;10(2):334. doi: 10.3390/antiox10020334

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Transcriptomics analysis reveals common senescence signalling pathways in senescent preadipocytes grown at 3% O₂ or atmospheric 20% O₂ conditions. (A) List of the number of statistically significant transcriptomics changes in senescent preadipocytes grown at either 3% O₂ or 20% O₂ and the number of common genes between the two conditions compared to their respective untreated control. Highlighted in red and green are the numbers of up-regulated and down-regulated gene products respectively. (B) Venn diagram shows the overlap of genes between senescent preadipocytes cultured at 3% O₂ and atmospheric O₂. (C) 10 most significant canonical pathways that are altered in senescent preadipocytes grown at 3% O₂, atmospheric O₂, and common genes as indicated. Axes show percentages of overlapped genes in each pathway and p-value of overlap (Ingenuity Pathway Analysis (IPA) generated). Highlighted in red and green is the percentage of up-regulated and down-regulated genes products in each pathway, respectively.