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. 2021 Feb 23;10(2):334. doi: 10.3390/antiox10020334

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Enriched pathway analysis of up-regulated transcriptome changes in senescent preadipocytes reveal critical activated pro-inflammatory pathways. (A) Ten most significantly up-regulated canonical pathways of senescence transcriptome changes by IPA. Axes demonstrate percentages of overlapped genes in each pathway and p-value of overlap. Shaded in red and green is the percentage of up-regulated and down-regulated genes in each pathway. (B) Table listing the 12 most significantly up-regulated extracellular annotated genes (putative senescence-associated secretory phenotype (SASP) molecules) in dataset along with their expression values in the indicated condition. (C) Table shows IPA predictions of the 10 most significantly activated key regulators in senescent preadipocytes based on assigned IPA p-values of overlap and the degree of activation is based on IPA assigned z-scores of activation; z-score value above +2 signifies activated pathways. (D) Table listing the 7 most significantly up-regulated signal transducer and activator of transcription (STAT)1/3 targets along with their expression values in the indicated conditions.