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. 2021 Feb 23;10(2):334. doi: 10.3390/antiox10020334

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Model of STAT1 and STAT3 regulation of inflammation and growth arrest phenotypes in senescent preadipocytes. This schematic diagram represents how STAT1 and STAT3 function antagonistically in regulating cGAS-STING mediated induction of CXCL10 and interferon signaling related genes and p53/p21-dependent growth arrest. STAT1 cooperates with cGAS/STING in driving the induction of CXCL10, and interferon signaling related genes such as IFNα, IFNβ, ISG15, MX and OASL2 and antagonizes the function of STAT3 in inhibiting p53-dependent growth arrest and cGAS-dependent induction of interferon signaling related genes.