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. 2021 Feb 22;22(4):2176. doi: 10.3390/ijms22042176

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© 2021 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Structural comparison between the MTD domain of METTL16 and the MTDs of human rRNA m⁶A MTases. All structural elements are color-coded as in Figure 3. Panels present superposition of human METTL16-MTD/hp1x/SAH structure with (A) METTL5/TRMT112/SAM complex (6h2u); (B) ZCCHC4 /SAH structure (6uca).