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. 2021 Feb 21;13(4):904. doi: 10.3390/cancers13040904

Figure 2.

Figure 2

A depiction of innate immune cells within the TME and a summary of the metabolic pathways that lead them to promote either immune activation or suppression. Major metabolic pathways are denoted in bold, with key signaling molecules listed below them. CARKL—carbohydrate kinase-like protein; cMYC - HIF-1α—hypoxia inducible factor 1-alpha; IKKɛ - IkB kinase-ɛ; iNOS—inducible nitric oxide synthase; mTOR—mammalian target of rapamycin; OxPHOS—oxidative phosphorylation; PGE2—prostaglandin E2; PI3K—phosphatidylinositol 3-kinase; PPAR—peroxisome proliferator-activated receptor; SREBP1—sterol regulatory element binding protein; TBK1—tank binding kinase 1.