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. Author manuscript; available in PMC: 2021 Mar 3.
Published in final edited form as: J Alzheimers Dis. 2020;77(4):1469–1482. doi: 10.3233/JAD-200019

Table 2.

Single variant analysis for TREM2, PLCG2, and ABI3 variants of interest using individuals with GWAs or WES data from ADSP, Knight-ADRC, and NIA-LOAD cohorts

Locus (variant) OR 95% CI P MAF cases MAF controls N
TREM2 (p.R62H) 1.49 1.16, 1.93 1.73 × 10−3 0.013 0.008 12,332
TREM2 (p.R47H) 4.38 2.84, 6.78 2.09 × 10−11 0.010 0.002 12,337
PLCG2 (p.P522R) 0.63 0.47, 0.85 2.16 × 10−3 0.006 0.009 12,360
ABI3 (p.S209F)* 1.59 1.20, 2.11 1.03 × 10−3 0.011 0.007 11,887

OR, odds ratio; CI, confidence interval;p,p-value; MAF, minor allele frequency; N, number of samples included in the analysis. Significant p-values after Bonferroni correction in bold.

*

The association analysis for this variant was run using WES/GWAs as covariate, in addition to SEX, PC1, PC2 and to account for the difference in genotyping rate between the GWAs data and the WES data.