Table 3.

Gene based analysis for TREM2, PLCG2, and ABI3 including rare (MAF < 1%) nonsynonymous variants, using 10,316 individuals with WES data from ADSP, Knight-ADRC, and NIA-LOAD cohorts

Locus	OR	95% CI	P	N
TREM2	1.99	1.52, 2.62	9.37 × 10−14	39
TREM2*	1.89	1.12, 3.20	2.59 × 10−05	38
TREM2**	1.69	1.50, 2.05	3.91 × 10−12	3
PLCG2	0.91	0.73, 1.12	0.064	136
PLCG2*	1.00	0.79, 1.28	0.683	135
PLCG2**	0.51	0.41,0.54	0.049	6
ABI3	1.44	1.07, 1.95	6.64 × 10−4	36
ABI3*	1.21	0.76, 1.90	0.127	35
ABI3**	2.49	2.07, 3.21	5.02 × 10−5	2

OR, odds ratio; CI, confidence interval; p, p-value; N, number of variants included.

^*gene-based analyses using the same variants but excluding variants of interest.

^**gene-based analyses using only the common variants across all cohorts Significant p-values after Bonferroni correction in bold.