. Author manuscript; available in PMC: 2021 Mar 3.

Published in final edited form as: J Alzheimers Dis. 2020;77(4):1469–1482. doi: 10.3233/JAD-200019

Table 5.

AD progression analysis for TREM2, PLCG2, and ABI3 variants of interest, using individuals with GWAs or WES data from Knight-ADRC and NIA-LOAD cohorts

Phenotype	Locus (variant)	Beta	SE	P	MAF _cases	N
Progression	TREM2 (p.R62H)	0.20	0.76	0.789	0.005	440
	TREM2 (p.R47H)	0.07	0.31	0.798	0.014	441
	PLCG2 (p.P522R)	−1.25	0.58	0.028	0.007	445
	ABI3 (p.S209F)	−0.24	0.57	0.677	0.006	438

SE, standard error; p, p-value; MAF, minor allele frequency; N, number of samples included. Significant p-values after Bonferroni correction in bold.