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. Author manuscript; available in PMC: 2021 Mar 3.
Published in final edited form as: JACC Heart Fail. 2019 Dec;7(12):1032–1041. doi: 10.1016/j.jchf.2019.08.018

Central Illustration. Intensive BP Reduction for Preventing Heart Failure: Potential Role of Diuretics.

Central Illustration.

SPRINT showed that intensive blood pressure reduction in older patients results in 36% fewer incident acute decompensated heart failure events (ADHF). However, some have questioned whether this was due merely to intergroup differences in diuretic medications. Detailed medication use data prospectively collected throughout the trial were examined and we found no evidence that the reduction in new ADHF events in SPRINT was due to differential diuretic use.