Fig. 1.

The pan-cancer landscape of KMT2 family mutations across human tumors. a Schematic representation of the domain structures (top) and transcription regulatory regions (bottom) for KMT2 family genes are shown. b The proportion of KMT2 family mutated tumors identified for each cancer type with alteration frequency in TCGA pan-cancer cohorts. c Mutation patterns (as Oncoprint schematics) across the KMT2 family hyper-altered patient cohorts from the TCGA database. Truncating mutations included nonsense, nonstop, splice site mutations, and frameshift insertion and deletion; Non-truncating mutations included missense mutations and inframe insertion and deletion. d Lollipop plot showing the loci distribution of mutations across the KMT2 family hyper-altered patient cohorts from the TCGA database. e Hazard ratio (HR) estimates for overall survival in TCGA pan-cancer cohorts. HRs compare KMT2 family mutation and wildtype status by using Cox regression. Plotting symbols give point estimates of HR and horizontal bars give 95% CIs