Table 3.

Univariate and multivariate analysis of disease-free-survival (DFS)

Covariables	Hazard ratio	95% CI	p value
Univariate analysis
PLR ≥ 150	0.986	0.654–1.488	0.948
NLR ≥ 2.5	1.203	0.821–1.761	0.343
LMR ≥ 2.5	0.444	0.289–0.683	0.001
Age	1.018	0.996–1.040	0.112
Sex (female)	0.970	0.595–1.579	0.901
Pathological stage			0.051*
I	1.000
II	1.686	1.126–2.526	0.011
III	1.793	0.812–3.958	0.148
IV	2.536	0.350–18.380	0.357
Histological type			0.219*
Adenocarcinoma	1.000
Squamous cell carcinoma	0.618	0.384–0.995	0.048
Large cell carcinoma	0.792	0.381–1.646	0.532
Other	0.568	0.138–2.343	0.434
Multivariate analysis
LMR ≥ 2.5	0.476	0.307–0.738	0.001
Age	1.029	1.005–1.054	0.017
Sex
Male	1.000
Female	1.171	0.693–1.977	0.556
Pathological stage			0.027*
I	1.000
II	1.779	1.174–2.695	0.007
III	1.878	0.848–4.162	0.120
IV	3.101	0.406–23.695	0.275
Histological type			0.053*
Adenocarcinoma	1.000
Squamous cell carcinoma	0.527	0.322–0.862	0.011
Large cell carcinoma	0.619	0.294–1.301	0.205
Other	0.541	0.127–2.306	0.407

LMR lymphocyte-to-monocyte ratio, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio

^*Linear trend p value