Figure 1.

Family pedigrees of two sets of mother–daughter pairs. A: SLS11 and SLS12. B: SLS9 and SLS10. Probands SLS11 (Family A) and SLS9 (Family B) are indicated with arrows. In Family A, an inversion-specific PCR test was used for genotyping 14 additional relatives, identifying four additional carriers (two CRC affected, and one in whom adenomas developed at age 34 years) and two additional obligate carriers (both unaffected). HP, hyperplastic polyp; TA, tubular adenoma; TV, tubulovillous adenoma