TABLE 1.

Baseline and follow‐up regional iron content in patients and controls

		Baseline	Follow‐up	g	Difference (95% CI)	% Change a (95% CI)
Thalamus	Controls	75.5 ± 18.8	76.0 ± 17.9	.03	+0.5 [−2.8, 3.7]	+0.7% [−3.7, 4.9]
	Multiple sclerosis	55.7 ± 19.7	52.9 ± 18.1	.15	−2.8 [−4.7, −0.9] b	−5.0% [−8.4, −1.6]
	g	1.02	1.28
	Difference (95% CI)	−19.8 (−26.8, −12.8) b	−23.1 (−26.8, −16.6) b
	% Change a (95% CI)	−26.2% [−35.5,‐16.9]	−30.4% [−35.3, −21.8]
Caudate	Controls	69.3 ± 12.0	70.9 ± 11.8	.13	+1.6 [−0.8, 4.1]	+2.3% [−1.2, 5.9]
	Multiple sclerosis	71.7 ± 12.3	70.0 ± 13.2	.14	−1.7 [−2.8, −0.7] b , c	−2.4% [−3.9, −1.0]
	g	.20	.07
	Difference (95% CI)	+2.4 (−2.4, 7.3)	−0.9 (−6.2, 3.2)
	% Change a (95% CI)	+3.5% [−3.5, 10.5]	−1.3% [−8.7, 4.5]
Putamen	Controls	116.2 ± 21.4	115.7 ± 22.3	.02	−0.5 [−2.8, 1.7]	+0.4% [−2.4, 1.5]
	Multiple sclerosis	112.0 ± 23.4	109.8 ± 24.6	.09	−2.2 [−3.8, −0.6] b	−2.0% [−3.4, 0.5]
	g	.18	.05
	Difference (95% CI)	−4.2 (−12.4, 4.1)	−5.9 (−14.5, 2.8)
	% Change a (95% CI)	−3.6% [−10.7, 3.5]	−5.1% [−12.5, 2.4]
Globus pallidus	Controls	70.3 ± 10.5	69.1 ± 9.3	.12	−1.2 [−2.9, 0.6]	−1.7% [−4.1, 0.9]
	Multiple sclerosis	73.7 ± 17.4	71.1 ± 17.0	.15	−2.6 [−3.7, −1.4] b	−3.5% [−5.0, −1.9]
	g	.12	.15
	Difference (95% CI)	+3.4 (−2.4, 9.1)	+2.0 (−3.6, 7.6)
	% Change a (95% CI)	+4.8% [−3.4, 12.9]	+2.9% [−5.2, 11.0]

Note: Results are presented as mean ± standard deviation and mean difference (95% CI), respectively. Iron content is stated in mg. Effect sizes were computed using Hedge's g.

Abbreviation: CI, confidence interval.

^a Percent difference corresponding to the mean change and 95% lower and upper bounds.

^b Significance after adjusting for false discovery rate at an alpha of q < 0.05.

^c q < 0.05 interaction effect of time by disease.