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. 2021 Mar 1;17(3):461–469. doi: 10.5664/jcsm.8934

Table 3.

Linear mixed model analysis of fixed effects of factors (tonic/phasic RSWA, sleep stage) on heart rate variability parameters in participants with iRBD.

Association of Tonic RSWA with HRV Association of Phasic RSWA with HRV
B 95% CI Boundary P B 95% CI Boundary P
Lower Upper Lower Upper
Normalized LF
RSWA −0.00263 −0.00437 −0.00089 .004* 0.00141 −0.00267 0.00550 .490
Sleep stage .003* .003*
 W 0 (ref) 0 (ref)
 N2 −0.08274 −0.16309 −0.00239 −0.01005 −0.07897 0.05887
 R 0.09869 0.01304 0.18434 0.11306 0.04698 0.17915
RSWA × sleep stage .016*
 W 0 (ref)
 N2 0.00271 −0.00437 0.00453
 R 0.00062 0.00090 0.00255
Normalized HF
RSWA 0.00263 0.00089 0.00437 .004* 0.00141 −0.00550 0.00267 .490
Sleep stage .003* .003*
 W 0 (ref) 0 (ref)
 N2 0.08274 0.00239 0.16309 −0.01005 −0.05887 0.07897
 R −0.09869 −0.18434 −0.01304 0.11306 −0.17915 −0.04698
RSWA × sleep stage .016*
 W 0 (ref)
 N2 −0.00271 −0.00453 0.00437
 R −0.00062 −0.00255 −0.00090
LF/HF ratio (L)
RSWA −0.12924 −0.02132 −0.00453 .003* 0.00531 −0.01453 0.02514 .593
Sleep stage .003* .004*
 W 0 (ref) 0 (ref)
 N2 −0.40574 −0.80675 −0.00472 −0.05614 −0.39795 0.28568
 R 0.49382 0.04655 0.94109 0.56396 0.21876 0.90916
RSWA × sleep stage .020*
 W 0 (ref)
 N2 0.01305 0.00398 0.02211
 R 0.00302 −0.00705 0.01309

(L) Parameters were log-transformed before performing linear mixed model analysis. *P < 0.05. HF = high frequency, LF = low frequency, RMSSD = root mean square difference of successive R-R intervals, RSWA = rapid eye movement sleep without atonia, SDNN = standard deviation of R-R intervals.