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. 2021 Mar 3;20:45. doi: 10.1186/s12943-021-01340-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Overexpression of FBW7 significantly suppresses ovarian cancer cell proliferation and growth in vitro and in vivo. a Stable overexpression of FBW7 in SKOV3 and OVCAR429 cells. The expression of FBW7 is verified at both mRNA and protein levels. b Overexpression of FBW7 significantly reduces the proliferation rate of SKOV3 and OVCAR429 cells. c Overexpression of FBW7 impairs the colony-forming ability of ovarian cancer cells. d Overexpression of FBW7 suppresses anchorage-independent growth ovarian cancer cells. e Overexpression of FBW7 promotes ovarian cancer cell apoptosis. f Overexpression of FBW7 in SKOV3 cells markedly suppresses ovarian tumor growth in the xenograft mice. g The size of tumors formed in the xenograft mice is monitored every 3 days. h Overexpression of FBW7 significantly reduces weight of tumors in the xenograft mice. Results were presented as mean ± SD of three independent experiments. *P < 0.05 or **P < 0.01 indicates a significant difference between the indicated groups