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. 2020 Dec 14;218(3):e20201416. doi: 10.1084/jem.20201416

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© 2020 He et al.

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Figure 2. — HFD enhances type 2 diabetic phenotype in Trx2^ADKO mice. (A) Growth curves of WT and Trx2^ADKO male mice fed the NCD or HFD (n = 8). (B) Hematoxylin and eosin–stained sections of eWAT from 14-wk-old WT and Trx2^ADKO mice fed the NCD or HFD for 8 wk. Diameters of adipocyte in eWAT and ingWAT were quantified. n = 8. Scale bars, 100 µm. (C) Fasting blood glucose levels and serum insulin levels of WT and Trx2^ADKO mice fed the NCD or HFD (n = 8). (D and E) GTT (D) and ITT (E) assays in 14-wk-old male WT and Trx2^ADKO mice fed the NCD or HFD for 8 wk (n = 8). AUC (120 min) was calculated (bottom panel). Quantitative data are presented as mean ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001 versus the indicated comparisons. Significance was assessed by one-way ANOVA followed by Tukey’s post hoc test.