Figure 1.

A) Pneumocytes distribution of Ace2 Receptor, ferroportin and transferrin receptors; B) Intracellular iron movements; C) Ace2 receptor stimulation and activation of NF-κB pathway with implementation of hepcidin, IL-6 and transferrin receptors; D) Ferroportin internalization trough hepcidin action and transferrin receptor exposition; E) Transferrin internalization with labile iron pool accumulation and initial Fenton chemistry; F) Excess of intracellular iron and consequent ferroptosis with free iron delivery and Macrophage iron capitation.