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. 2021 Feb 17;12:628621. doi: 10.3389/fphar.2021.628621

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Copyright © 2021 Zhai, Zhang, Hei, Jin, Han, Ko, Yu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Isorhamnetin repressed GBC cell migration and invasion. (A,B) Cell migration and invasion of NOZ and GBC-SD detected after isorhamnetin treatment (0, 40, 60, 80 μM) for 18 h. The migrated cell numbers were computed in five random fields in each group. (C) The expression levels and statistic results of MMP-2, Slug, MMP-9, E-cadherin, N-cadherin, and TWIST1 in NOZ and GBC-SD after isorhamnetin treatment. GAPDH was used as the loading control. *p < 0.05, **p < 0.01, ***p < 0.001, relative to the control group.