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. 2021 Feb 17;12:628621. doi: 10.3389/fphar.2021.628621

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Copyright © 2021 Zhai, Zhang, Hei, Jin, Han, Ko, Yu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Isorhamnetin triggers cell cycle arrest in the G2/M phase and regulates PI3K/AKT cascade. (A) Cell cycle phases of NOZ and GBC-SD cells exposed to isorhamnetin (0, 40, 60, and 80 μM) for 48 h analyzed using flow cytometry. (B) Cell cycle phase distribution indicated as the mean ± SD (n = 3). (C) Levels of expression of cyclin B1, CDK1, p27, and p53 were determined using western blot assessment. (D) The expression levels of p-PI3KP85α/γ/β-Y467/Y199/Y464, p-AKT1 (T450), PIK3CA, and AKT were detected. *p < 0.05, **p < 0.01 relative to the control group.