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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Obesity (Silver Spring). 2021 Mar;29(3):569–578. doi: 10.1002/oby.23081

Figure 1. POMMS study design.

Figure 1.

Adolescents between 10 and 18 with either BMI >5th %ile to < 85th percentile (healthy weight controls, or HWC) or BMI equal to or over the 95th percentile (adolescents with obesity, or OB) were recruited to join the study. Target numbers of recruits for each intervention are indicated, along with actual recruitment numbers. Age matched HWC recruits had clinical measurements of health as well as serum, stool, and PBMCs collected at a single timepoint, while OB recruits were evaluated and offered a treatment arm that was clinically relevant depending on the individual. OB recruits then had clinical measurements of health, blood, PBMC and stool samples taken at baseline, 3 months, and 6 months (or termination) of the study. Stool samples were also collected from OB patients at 1.5 and 4.5 months after the first visit. All samples are stored in replicates in the POMMS Biorepository managed within the Duke Children’s Biobank to be made available for research purposes.