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. Author manuscript; available in PMC: 2021 Mar 3.
Published in final edited form as: Cell Rep. 2020 Nov 3;33(5):108330. doi: 10.1016/j.celrep.2020.108330

Figure 6. C4A Lessens Autoantibody Production in the 564Igi Lupus Model.

Figure 6.

(A) Volcano plot comparison of median IgG signal intensities in C4A 564Igi (n = 8) relative to C4B 564Igi (n = 10) mice. Log2(fold change) appears on the x axis. Significance (presented as −10 × log10[p value]) is on the y axis. The p value was obtained running multiple unpaired t tests corrected with the Holm-Sidak method. One dot represents 1 self-Ag.

(B–D) Dosage of anti-Ro60, -BPI, and -CTGF IgG titers in serum of 15–20 wo C4−/−, C4A, C4B, and C4+/+ 564Igi by ELISA. Means ± SEMs; 1 dot represents 1 mouse; n > 4; 1-way ANOVA with Tukey’s test; *p < 0.05.

See also Figure S6 and Table S6.