TABLE 1.
Clade classification, mechanism of azole resistance, and susceptibility of C. auris to lopinavir, fluconazole, voriconazole, and itraconazole
|
C. auris isolate |
Clade | Mechanism(s) of azole resistance | MIC (μg/ml)a |
|||
|---|---|---|---|---|---|---|
| LPV | FLC | VRC | ITC | |||
| AR0381 | II | None | >128 | 1 | 0.0078 | 0.125 |
| AR0382 | I | None | >128 | 1 | 0.0625 | 0.25 |
| AR0383 | III | ERG11 mutation (F126L, V125A), overexpression of CDR1 | >128 | 256 | 0.5 | 0.5 |
| AR0384 | III | ERG11 mutation (F126L, V125A), overexpression of CDR1 | >128 | 128 | 0.5 | 0.25 |
| AR0385 | IV | ERG11 mutation (Y132F, K177R, N335S, E343D), overexpression of CDR1 | >128 | 256 | 4 | 0.5 |
| AR0386 | IV | ERG11 mutation (Y132F, K177R, N335S, E343D), overexpression of CDR1 | >128 | 256 | 2 | 0.5 |
| AR0387 | I | None | >128 | 1 | 0.0312 | 0.125 |
| AR0388 | I | ERG11 mutation (K143R), overexpression of CDR1 and MDR1 | >128 | 256 | 0.5 | 1 |
| AR0389 | I | ERG11 mutation (Y132F), overexpression of CDR1 | >128 | 256 | 2 | 1 |
| AR0390 | I | ERG11 mutation (K143R), overexpression CDR1 and MDR1 | >128 | 256 | 0.5 | 1 |
a
LPV, lopinavir (LPV); FLC, fluconazole; VRC, voriconazole; ITC, itraconazole.