TABLE 2.
Effects of lopinavir on the antifungal activity of fluconazole, voriconazole, and itraconazole against C. auris
|
C. auris isolate |
LPV/FLC combination |
LPV/VRC combination |
LPV/ITC combination |
||||||
|---|---|---|---|---|---|---|---|---|---|
| MIC (μg/ml) | ƩFICa | Mode | MIC (μg/ml) | ƩFIC | Mode | MIC (μg/ml) | ƩFIC | Mode | |
| AR0381 | 0.5/0.5 | 0.53 | IND | 8/0.0039 | 0.53 | IND | 2/0.00098 | 0.04 | SYN |
| AR0382 | 1/0.25 | 0.31 | SYN | 8/0.0156 | 0.31 | SYN | 8/0.0019 | 0.08 | SYN |
| AR0383 | 2/128 | 0.56 | IND | 8/0.25 | 0.53 | IND | 8/0.0019 | 0.07 | SYN |
| AR0384 | 2/128 | 1.06 | IND | 8/0.25 | 0.53 | IND | 8/0.0078 | 0.09 | SYN |
| AR0385 | 2/128 | 0.56 | IND | 4/0.5 | 0.19 | SYN | 8/0.0078 | 0.05 | SYN |
| AR0386 | 16/128 | 0.53 | IND | 4/0.25 | 0.19 | SYN | 8/0.0078 | 0.05 | SYN |
| AR0387 | 0.5/1 | 1.03 | IND | 4/0.0156 | 0.53 | IND | 8/0.00098 | 0.04 | SYN |
| AR0388 | 8//32 | 0.19 | SYN | 8/0.0625 | 0.19 | SYN | 2/0.0039 | 0.07 | SYN |
| AR0389 | 8/128 | 0.56 | IND | 8/0.5 | 0.31 | SYN | 2/0.0078 | 0.07 | SYN |
| AR0390 | 8//16 | 0.13 | SYN | 8/0.0625 | 0.19 | SYN | 4/0.0039 | 0.07 | SYN |
a
The fractional inhibitory concentration index (ΣFICI) was used to quantify the interactions between the tested combinations based on the following definitions: synergy (SYN) at ΣFICI values of ≤0.5, indifference (IND) at ΣFICI values ranging from >0.5 to ≤4, and antagonism at ΣFICI values of >4.