TABLE 3.
List of differentially expressed genes for C. auris AR0390 treated with itraconazole (1 μg/ml)
| ID | Name | Log2 fold change | P value | CGDa description |
|---|---|---|---|---|
| 40028953 | CAN1 | 3.4505 | 3.5 × 10−10 | Basic amino acid permease |
| 40025718 | FRE3 | 2.7106 | 1.09 × 10−6 | Protein with similarity to ferric reductase Fre10p |
| 40028243 | ERG24 | 2.3585 | 5.2 × 10−5 | C-14 sterol reductase with a role in ergosterol biosynthesis |
| 40030120 | PGA31 | 2.3457 | 7.7 × 10−5 | Protein associated with cellular response to chemical stimulus |
| 40030199 | DDR48 | 2.1539 | 3.7 × 10−4 | Stress-associated protein, induced by benomyl, caspofungin, and ketoconazole |
| 40029187 | MDR1 | 2.1045 | 4.4 × 10−4 | Plasma membrane MDR/MFS multidrug efflux pump |
| 40027842 | RCT1 | 2.1026 | 4.5 × 10−4 | Fluconazole-induced protein, required for caspofungin tolerance |
| 40028209 | PRA1 | 2.0941 | 4.5 × 10−4 | Cell surface protein that sequesters zinc from host tissue |
| 40026925 | DIP5 | 1.9692 | 4.7 × 10−4 | Dicarboxylic amino acid permease |
| 40025268 | PGA30 | 1.9233 | 3.1 × 10−4 | Predicted GPI-anchored protein |
| 40030546 | DAL81 | −2.0262 | 3.7 × 10−4 | RNA polymerase II repressing transcription factor binding activity |
| 40028527 | TDH3 | −2.0678 | 4.8 × 10−4 | NAD-linked glyceraldehyde-3-phosphate dehydrogenase |
| 40029413 | JEN2 | −2.1117 | 4.4 × 10−4 | Dicarboxylic acid transporter |
| 40027889 | YHB1 | −2.245 | 1.2 × 10−4 | Nitric oxide dioxygenase |
| 40029539 | ADH1 | −2.3056 | 7.7 × 10−5 | Alcohol dehydrogenase |
| 40029385 | LIP2 | −2.3233 | 4.5 × 10−4 | Secreted lipase |
| 40027170 | HGT8 | −2.7557 | 6.1 × 10−7 | High-affinity glucose transporter of the major facilitator superfamily |
| 40027169 | HGT6 | −2.9273 | 9.6 × 10−8 | Putative MFS glucose transporter |
a
Descriptions of the identified differentially expressed genes (DEGs) were obtained from the Candida Genome Database (CGD) supplemented by a tBLASTx search. ID, identifier; GPI, glycosylphosphatidylinositol.