TABLE 4.

List of differentially expressed genes for C. auris AR0390 treated with a combination of lopinavir (10 μg/ml) and itraconazole (1 μg/ml)

ID	Name	Log2 fold change	P value	CGDa description
40025268	PGA30	2.4588	2.6 × 10−5	Protein with unknown function
40025718	FRE3	2.1689	3.4 × 10−4	Protein with similarity to ferric reductase Fre10p
40028953	CAN1	2.7975	1.3 × 10−6	Basic amino acid permease
40030199	DDR48	2.5766	7.4 × 10−6	Stress-associated protein, induced by benomyl, caspofungin, and ketoconazole
40027842	RCT1	2.4473	2.3 × 10−5	Fluconazole-induced protein, required for caspofungin tolerance
40029690	RTA3	2.4239	2.9 × 10−5	Putative lipid translocase that influences the susceptibility of C. albicans to fluconazole
40028243	ERG24	2.2803	9.3 × 10−5	C-14 sterol reductase with a role in ergosterol biosynthesis
40030120	PGA31	2.2697	1.6 × 10−4	Cellular response to chemical stimulus
40027170	HGT8	−1.9543	2.4 × 10−4	High-affinity glucose transporter of the major facilitator superfamily
40027169	HGT6	−2.7443	1.3 × 10−6	Putative MFS glucose transporter

^aDescriptions of the identified DEGs were obtained from the Candida Genome Database supplemented by a tBLASTx search.