TABLE 3.
PK/PD parameters at steady state after intermittent and continuous dosing of fosfomycin
| MIC (mg/liter) | Mean AUCSS,0–24/MIC ratio ± SD |
Mean %T>MIC ± SD |
Mean Cmax/MIC ratio ± SD |
|||
|---|---|---|---|---|---|---|
| INT | CON | INT | CON | INT | CON | |
| 16 | 229.90 ± 37.62 | 275.70 ± 53.9 | 100 ± 0 | 100 ± 0 | 34.47 ± 4.23 | 11.49 ± 2.25 |
| 32 | 114.95 ± 18.81 | 137.85 ± 26.95 | 97.79 ± 4.2 | 100 ± 0 | 17.23 ± 2.12 | 5.74 ± 1.12 |
| 64 | 57.48 ± 9.4 | 68.92 ± 13.47 | 74.20 ± 10.09 | 100 ± 0 | 8.62 ± 1.06 | 2.87 ± 0.56 |
| 128 | 28.74 ± 4.7 | 34.46 ± 6.74 | 43.72 ± 7.83 | 100 ± 0 | 4.31 ± 0.53 | 1.44 ± 0.28 |
| 256 | 14.37 ± 2.35 | 17.23 ± 3.37 | 17.66 ± 5.91 | 0 ± 0 | 2.15 ± 0.26 | 0.72 ± 0.14 |