TABLE 1.
Antibiotic and phage susceptibility of bacterial colonies isolated from the lung homogenate before and after treatment with phage PEV31 or PBS
| Time postinfection (h) | Treatmentb | No. of colonies observed (tested) | MIC (μg/ml)a |
PEV31 susceptibilityb | ||||
|---|---|---|---|---|---|---|---|---|
| Amikacin (R > 16) | Ciprofloxacin (R > 0.5) | Tobramycin (R > 2) | Aztreonam (R > 16) | Colistin (R > 2) | ||||
| 0 | NA | 4 (4) | >64 | 32 | 32 | >64 | 8 | S |
| 26 | PBS | 4 (4) | >64 | 32 | 32 | >64 | 8 | S |
| 26 | Phage | 4 (10) | 16 | 0.125 | 8 | >64 | 64 | R |
| 26 | Phage | 6 (10) | >64 | 32 | 32 | >64 | 8 | S |
a
MIC breakpoints (R) from EUCAST (v. 10.0) for Pseudomonas spp. are given under each antibiotic.
b
NA, not applicable; PBS, phosphate-buffered saline; S, susceptible; R, resistant.