TABLE 5.

Study definitions^a

Term(s)	Definition
Steady-state vancomycin trough	Vancomycin trough collected no earlier than prior to the 4th dose
Trough target range	Vancomycin serum concn of 10–20 mg/liter
Observed trough	Steady-state vancomycin trough observed
Predicted trough	Steady-state vancomycin trough predicted from the best model
Residual	Observed trough − predicted trough
Expected trough	15 (median of goal range) + residual
eAUCobserved, eAUCexpected	Estimated (1-level) 24-h area under the curve using the equation $\text{eAUC}=\frac{\text{dose}\left(\text{mg/kg}\right)\times 24}{\text{ln}\left(\frac{\text{trough}+\frac{\text{dose}\left(\text{mg/kg}\right)}{V\text{(liters/kg)}}}{\text{trough}}\right)\times V\text{(liters/kg)}}$ where the inputs include observed trough for eAUCobserved or expected trough for eAUCexpected dose (mg/kg), maintenance dose using total body wt V (liters/kg), population estimate of the vol of distribution (estimated as 0.3 liters/kg or 0.7 liters/kg total body wt)

^aTroughs are in milligrams per liter, and areas under the curve are in milligrams per hour per liter. eAUC, estimated area under the curve.