TABLE 4.

In vitro activities of cefepime-zidebactam and comparators tested against 515 isolates of A. baumannii and 408 isolates of carbapenem-resistant A. baumannii collected in China, 2018^a

Antimicrobial agent	A. baumannii (n = 515)					Carbapenem-resistant A. baumannii (n = 408)
	MIC (mg/liter)			R, %	S, %	MIC (mg/liter)			R, %	S, %
	Range	50%	90%			Range	50%	90%
Cefepime-zidebactam	≤0.03 to >64	16	32	36.5	26	2 to >64	16	32	46.1	8.8
Ceftazidime-avibactam	0.125 to >64	64	>64	84.9	15.1	4 to >64	64	>64	98.8	1.2
Ceftolozane-tazobactam	≤0.06 to >128	32	128	80.6	17.9	0.5 to >128	64	128	99	0.7
Cefepime-tazobactam	≤0.03 to >64	64	>64	78.1	20	2 to >64	>64	>64	97.8	1
Piperacillin-tazobactam	≤2 to >256	>256	>256	81.4	16.3	8 to >256	>256	>256	98.5	1
Cefoperazone-sulbactam	≤1 to >128	128	>128	79.8	18.3	4 to >128	128	>128	96.8	1.5
Cefazolin	4 to >32	>32	>32	99.6	0	>32 to >32	>32	>32	100	0
Cefuroxime	4 to >32	>32	>32	95.1	1.2	8 to >32	>32	>32	99.8	0.2
Ceftriaxone	0.5 to >32	>32	>32	82.3	8.5	8 to >32	>32	>32	98.8	0.2
Ceftazidime	≤0.25 to >32	>32	>32	81.9	17.3	2 to >32	>32	>32	98.3	1.2
Cefepime	≤0.06 to >128	128	>128	79.8	18.4	2 to >128	128	>128	98.3	0.7
Aztreonam	≤1 to >128	64	128	86.8	4.7	8 to >128	64	128	97.5	0.2
Imipenem	0.125 to >128	64	128	78.8	20	4 to >128	64	128	99.5	0
Meropenem	≤0.03 to >64	64	>64	78.8	19.8	2 to >64	64	>64	99.5	0.2
Amikacin	≤1 to >128	>128	>128	76.1	23.5	≤1 to >128	>128	>128	92.2	7.6
Ciprofloxacin	≤0.06 to >8	>8	>8	82.5	17.5	0.125 to >8	>8	>8	98.3	1.7
Levofloxacin	≤0.125 to >16	8	32	78.3	17.9	≤0.125 to >16	8	32	94.6	1.5
Trimethoprim-sulfamethoxazole	≤0.25 to >32	>32	>32	69.3	30.7	≤0.25 to >32	>32	>32	82.4	17.6
Polymyxin B	0.25 to >16	1	2	2.5	97.5	0.25 to >16	1	2	3.2	96.8
Tigecycline	≤0.06 to 16	1	2	NA	NA	0.125 to 16	1	2	NA	NA

^aNA, not available; R, resistant; S, susceptible.