TABLE 2.
MICs of the last antibiotic agent and distance between a reference point, equidistant from each MIC, and the last inhibitory line
| Antibiotic agenta | MICb (μg/ml) | Distance between MIC lines in combination therapy vs. single therapy (mm) |
|---|---|---|
| Single agent | ||
| FOF | 3 | |
| VAN | 3 | |
| DAP | 3 | |
| LZD | 2 | |
| 2nd agent | ||
| IPM/CS+FOF | 0.38 | 8 |
| IPM/CS+VAN | 1.5 | 3 |
| FOF+VAN | 2 | 2 |
| IPM+DAP | 1.5 | 3 |
| FOF+DAP | 1.5 | 3 |
| IPM+LZD | 0.75 | 4 |
| FOF+LZD | 1 | 3 |
| 3rd agent | ||
| IPM+FOF+VAN | 0.75 | 6 |
| IPM+FOF+DAP | 0.75 | 6 |
| IPM+FOF+LZD | 0.38 | 7 |
a
IPM/CS, imipenem/cilastatin; FOF, fosfomycin; VAN, vancomycin; DAP, daptomycin; LZD, linezolid.
b
Determined by Etest.