FIG 2.
Final rifampin pharmacokinetic model. Abbreviations: Vc, central volume of distribution; VCSF, volume of distribution of CSF compartment; ktr, transfer rate constant; QCSF, intercompartmental clearance between central and CSF compartments; fu, fraction unbound; PC, penetration fraction from central to CSF compartment; KENZ in, zero-order enzyme production rate; KENZ out, first-order rate constant of enzyme degradation; Emax, maximum enzyme induction; EC50, drug concentration that results in half of Emax; ENZ, the amount of metabolizing enzyme in the enzyme pool; F, relative bioavailability; Cp, plasma concentration.