FIG 3.

Exposure and probability of target attainment in different isoniazid dosing scenarios. The panels in the top row show box-and-whisker plots (the lower and upper limits of individual boxes denote the 25th and 75th percentiles, and the whiskers represent percentiles 2.5 and 97.5) of simulated steady-state plasma and CSF exposure from 0 to 24 h (AUC_0–24) of isoniazid. The broken lines represent the plasma/CSF targets of isoniazid; i.e., the lower blue line represents the EC₅₀ (7.03 mg × h/liter) and the upper red line represents the EC₉₉ (98.6 mg × h/liter) associated with survival in adults with TBM (24). The panels in the two lower rows show the probability of target attainment (PTA) for isoniazid at steady state in plasma and CSF. The shaded bands represent the currently recommended WHO dose of isoniazid.