FIG 5.
Exposure and probability of target attainment in different pyrazinamide dosing scenarios. The panels in the top row show box-and-whisker plots (the lower and upper limits of individual boxes denote the 25th and 75th percentiles, and the whiskers represent percentiles 2.5 and 97.5) of simulated steady-state plasma and CSF peak concentrations (Cmax) of pyrazinamide. The broken red lines represent the plasma/CSF targets of pyrazinamide (31.5 mg/liter) derived from the target for the treatment of pulmonary TB in adults (17). The panels in the bottom row show the probability of target attainment (PTA) for pyrazinamide at steady state in plasma and CSF. The shaded bands represent the dose of pyrazinamide currently recommended by WHO.