FIG 6.
Exposure and probability of target attainment in different ethambutol dosing scenarios. The left panel shows box-and-whisker plots (the lower and upper limits of individual boxes denote the 25th and 75th percentiles, and the whiskers represent percentiles 2.5 and 97.5) of simulated steady-state plasma peak concentrations (Cmax) of ethambutol. The broken red line represents the plasma target of ethambutol (2.0 mg/liter) derived from the target for the treatment of pulmonary TB in adults (17). The right panel shows the probability of target attainment (PTA) for ethambutol at steady state in plasma. The shaded bands represent the dose of ethambutol currently recommended by WHO.