TABLE 2.

Safety parameters and laboratory abnormalities upon diagnosis of pneumonia^e

Safety or laboratory parameter	No. (%) of animals
	Control (n = 6)	Linezolid (n = 6)	Telavancin (n = 6)
Skin rash	0 (0)	0 (0)	0 (0)
Bronchospasm	0 (0)	0 (0)	0 (0)
Diarrhea	0 (0)	0 (0)	0 (0)
Vomiting	0 (0)	0 (0)	0 (0)
Hb reductiona	1 (16.7)	0 (0)	0 (0)
Platelet count reductiona	2 (33.7)	3 (50.0)	1 (16.7)
ALT level > ULN	1 (16.7)	2 (33.7)	1 (16.7)
Alkaline phosphatase level > 2× ULN	1 (16.7)	1 (16.7)	0 (0)
Abnormal potassium levelb	1 (16.7)	1 (16.7)	0 (0)
Creatinine level increasec	0 (0)	4 (66.7)	1 (16.7)
Creatinine level of >1.5 mg/dl	1 (16.7)	4 (66.7)	0 (0)
Urinary output reductiond	2 (33.7)	2 (33.7)	0 (0)
Furosemide administration	3 (50.0)	4 (66.7)	0 (0)

^aAt least a 30% reduction from the value at pneumonia diagnosis.

^bPotassium level of <3.5 or >5.5 meq/liter.

^cSerum creatinine level increase of ≥25% from that at pneumonia diagnosis.

^dUrinary output of ≤0.5 ml · h/kg.

^eHb, hemoglobin; ALT, alanine aminotransferase; ULN, upper limit of normal.