FIG 2.

Divergent effects of MET on control (CON) and T2D mice. (a) Seven days p.i., a group of mice were sacrificed and assessed for lung bacterial loads. Forty-five days p.i., treated and untreated mice from control and T2D groups were assessed for viable bacteria in lung (b), lung inflammation (c), and serum IL-12p40 levels (d). Results are presented as individual data points (a–d) and representative images (25×) (c) from 2 pooled independent experiments (n = 7–10 mice/group). *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001, by Student's t test (b, c) and one-way analysis of variance followed by Dunnett’s multiple-comparison test (b–d). UNT, untreated.