FIG 6.

Effect of combined fluconazole plus shCD5 therapy in C. albicans-infected CD1 mice. Shown is the survival percentage over time of CD1 mice infected with C. albicans (3 × 10³ CFU/g, i.v.) and either left untreated (vehicle; n = 8) or treated with daily FLC doses (1 mg/kg, i.p.; n = 10) for 1 week (starting at 48 h postinfection), with single-dose shCD5 (1.25 mg/kg, i.v.; n = 8) given at 18 h postinfection, or with a combination of the latter two (shCD5 + FLC; n = 10). Statistical differences between treated and control groups were analyzed by log rank (Mantel-Cox) test. *, P ≤ 0.05; ****, P ≤ 0.0001.