FIG 2.

Copy-number variations (CNV) of C. auris after a series of passages in the fluconazole-containing medium. Fluconazole-susceptible strain BJCA001 served as a reference. Experimentally evolved strains A1 to A8 and B1 to B8 (Fig. 1) were tested. A comparative genomic analysis shows a copy number variation at scaffold 6 (chromosome V) using the B8441 genome assembly as a reference. The data for strains A9 to A18 are presented in Fig. S1. The x axis indicates scaffolds 1 to 10. The y axis shows the copy number of each scaffold. Each spot represents the sequence depth for a genomic segment of 500 bp across the chromosomes.