TABLE 1.
Differentially expressed genes of interest on chromosome V of C. aurisa
| Functional description | C. auris gene accession no. | C. albicans homolog | Log2(WT/B1) | FDR | Reference(s) |
|---|---|---|---|---|---|
| Ergosterol biosynthesis | PIS49477.1 | ERG13 | −0.61 | 1.27E−06 | 26, 55 |
| PIS49563.1 | ERG9 | −1.18 | 5.61E−26 | 26, 55 | |
| PIS49684.1 | NCP1 | −2.06 | 3.72E−54 | 39 | |
| PIS49856.1 | ZCF22 | −1.12 | 3.64E−15 | 40, 41 | |
| CDR or MDR family | PIS49792.1 | TAC1A | −1.61 | 3.52E−33 | 27 |
| PIS49793.1 | TAC1B | −0.59 | 8.32E−05 | 27 | |
| PIS49714.1 | orf19.1449 | −0.66 | 5.79E−04 | 56 | |
| PIS49547.1 | orf19.2473 | −0.62 | 4.14E−10 | 55 | |
| Oligopeptide transporters | PIS49539.1 | OPT1 | −1.48 | 3.22E−04 | 11 |
| PIS49578.1 | OPT1 | 0.47 | 2.59E−05 | 11 | |
| PIS49456.1 | OPT2 | −0.32 | 3.30E−03 | 11 | |
| PIS49514.1 | OPT2 | −0.61 | 3.71E−03 | 11 | |
| PIS49515.1 | OPT2 | −0.16 | 5.62E−01 | 11 | |
| PIS49521.1 | OPT2 | −1.05 | 3.86E−12 | 11 | |
| PIS49522.1 | OPT2 | −1.62 | 1.66E−19 | 11 | |
| PIS49537.1 | OPT2 | −0.55 | 1.74E−03 | 11 | |
| Other major facilitator superfamily | PIS49770.1 | HGT7 | −1.97 | 3.84E−53 | 57 |
| PIS49560.1 | orf19.4090 | −0.82 | 1.11E−05 | 57 | |
| PIS49745.1 | orf19.4905 | −1.17 | 1.77E−33 | 57 | |
| PIS49665.1 | orf19.7666 | −0.62 | 1.18E−04 | 57 | |
| Fluconazole resistance related | PIS49757.1 | orf19.2893 | −1.25 | 4.24E−24 | 58 |
| PIS49801.1 | GRP2 | −1.99 | 1.94E−10 | 58 | |
| PIS49656.1 | orf19.6502 | −0.61 | 6.22E−07 | 58 |
a
This table is associated with Data Set S3. Log2(WT/B1) is the log2 ratio of the FPKM value of the WT to that of B1. FDR (false discovery rate) reflects adjusted P values. CDR, Candida drug resistance genes; MDR, multidrug resistance genes. The WT strain was BJCA001; B1 is a fluconazole-resistant strain derived from BJCA001.