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. 2020 Apr 23;106(3):746–758. doi: 10.3324/haematol.2019.239970

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Copyright© 2021 Ferrata Storti Foundation

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Figure 5. — Impact of each mRNA feature on the translation efficiency and transcript stability. (A) Cumulative frequency representation of translation efficiency changes for mRNAs with the highest and lowest codon adaptation index (CAI), the largest and lowest 3’UTR ΔG.base-1 or 5’UTR ΔG.base-1 and the largest and shortest lengths. (B) Cumulative frequency representation of stability changes (Log2 [FC] transcriptome) of transcripts with the highest and lowest CAI, the largest and lowest 3’UTR ΔG.base-1 or 5’UTR ΔG.base-1 and the largest and shortest lengths. Distances were calculated using the Kolmogorov-Smirnov test. Exact P-values were calculated.