Figure 5.
Functional implications of stem cell factor in chronic lymphocytic leukemia cells. (A) Immunohistochemical staining showing weak nuclear immunopositivity for c-Kit of the scarce chronic lymphocytic leukemia (CLL) cells residing in the lymph nodes. (B) Real-time quantitative polymerase chain reaction analysis of KIT transcripts in stem cell factor (SCF)high CLL cases and SCFlow CLL cases. (C) Mitochondrial mass in CLL cells treated or not (control) with 100 ng/mL SCF for 48 h. Interconnected dots represent one case in two different conditions and bars represent median values. The Wilcoxon P test was applied to evaluate statistical significance; *P<0.05, **P<0.01, ***P<0.001. FD: fold difference.