Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 20;106(3):838–846. doi: 10.3324/haematol.2019.236836

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright© 2021 Ferrata Storti Foundation

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

PMC Copyright notice

Figure 3. — Dickkopf-1 (DKK1)3-76-long peptide (LP) efficiently induces DKK1-specific CD4+ T-cell response in vivo. Shown are CD4+ T-cell responses induced in HLADR *4-transgenic mice after immunization with DKK13-76 -LP or HLA-DR-restricted P30 short peptide. (A) Carboxyfluorescein succinimidyl ester (CFSE) dilution assay showing the percentages of proliferating CD4+ T cells from the spleen of mice after ex vivo re-stimulation with dendritic cells (DC) pulsed, but not unpulsed, with DKK13-76 LP or DKK1-P30 short peptide. Representative results from one of three independent experiments are shown. (B) Flow cytometry analysis showing the percentages of IFN-g-expressing or FoxP3+ CD4+ T cells from the spleen of mice after ex vivo re-stimulation with DC pulsed, but not unpulsed, with DKK13-76 LP or DKK1- P30 short peptide. Representative results from one of four experiments are shown.