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. 2020 Feb 20;106(3):838–846. doi: 10.3324/haematol.2019.236836

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Figure 4. — Dickkopf-1 (DKK1)3-76-long peptide (LP) induces DKK1-specific humoral immune response in vivo. Serum titers of DKK1-specific antibodies in mice after immunization with DKK13-76-LP or short peptide are shown. (A) ELISA showing the titers of DKK1-specific IgG antibodies in HLA-A*0201-transgenic mice immunized with DKK13-76 LP or P20. (B) ELISA showing the titers of DKK1-specific IgG antibodies in HLA-DR*4- transgenic mice immunized with DKK13-76 LP or P30. (C) Effect of DKK1 on differentiation of human osteoblasts in culture with the addition of control mouse IgG, anti-DKK1 antibody (R&D Systems) or serum from DKK13-76 LP vaccinated (after the 4th vaccination) HLA-A*0201-transgenic mice. Results of three experiments are shown. DMSO: dimethyl sulfoxide. *P<0.05; **P<0.01.