FIG 3.

Effect of CARD9 deficiency on the production of cytokines and chemokines in BALFs after pneumococcal infection. BALFs were collected from infected mice at 24 h after pneumococcal infection and the cytokines and chemokines in these BALFs were measured by enzyme-linked immunosorbent assay (ELISA). Each column represents the mean ± SD of five to eight mice. Tumor necrosis factor alpha (TNF-α), keratinocyte-derived chemokine (KC), and macrophage inflammatory protein-2 (MIP-2) production in BALFs were attenuated in CARD9 KO mice (A), but not in dectin-2 KO mice (B), compared to that in each genotype’s respective control mice. *, P < 0.05; ***, P < 0.005; NS, not significant.